Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to your minimum amount expected. Keep track of closely for signs of respiratory depression and sedation.
nalbuphine decreases effects of fentanyl by pharmacodynamic antagonism. Stay away from or Use Alternate Drug. Coadministration of mixed agonist/antagonist and partial agonist opioid analgesics may possibly cut down fentanyl's analgesic effect and possibly precipitate withdrawal symptoms.
lonapegsomatropin will reduce the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
fentanyl will improve the level or effect of tinidazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
fentanyl and buprenorphine buccal each increase sedation. Stay away from or Use Alternate Drug. Limit use to patients for whom alternative treatment options are insufficient
If coadministration of CYP3A4 inhibitors with fentanyl is important, keep an eye on patients for respiratory depression and sedation at Recurrent intervals and consider fentanyl dose adjustments until eventually stable drug effects are obtained.
nevirapine will minimize the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Intently. Coadministration of fentanyl with CYP3A4 inducers may lead into a decrease in fentanyl plasma concentrations, deficiency of efficacy or, perhaps, development of the withdrawal syndrome inside of a affected person who has formulated physical dependence to fentanyl.
If you need to cease using fentanyl, talk with your doctor first. Your dose is usually reduced progressively so you do not get withdrawal symptoms.
pirtobrutinib will increase the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
If you must go to A&E, will not travel yourself. Get some other person to travel you or demand an ambulance.
After stopping a CYP3A4 inducer, as the effects from the inducer decrease, the fentanyl plasma concentration will improve which could improve or prolong each the therapeutic and adverse effects.
Watch Closely (one)nirmatrelvir/ritonavir will enhance the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Use caution when picking out dosage for an elderly affected individual, normally commencing at low conclude of dosing variety, reflecting bigger frequency of reduced hepatic, renal, or cardiac functionality and of concomitant sickness or other drug therapy; because aged patients are more likely to acquire reduced renal purpose, care needs to be taken in dose range, and may be handy to monitor renal purpose
fentanyl and fentanyl intranasal both raise sedation. Keep away from fentanyl survivor or Use Alternate Drug. Limit use to patients for whom alternative treatment options are insufficient